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Steps Against the Burden of Parkinson's Disease

RecruitingNAAges 18 Years - anyAllThe University of New South Wales
NCT07057219 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Parkinson's Disease Treadmill Training RCT Summary Parkinson's disease (PD) affects over 10 million people globally. Despite optimal pharmacological treatment, approximately 70% of individuals experience unstable gait and falls, leading to loss of confidence, social isolation, fractures, and frequent hospitalisations. Treadmill training-especially when augmented by mechanical or virtual-reality perturbations-has shown promise in improving gait and reducing fall risk. However, the mechanisms underlying these benefits remain poorly understood, limiting the ability to personalise interventions effectively. This randomised controlled trial (RCT) forms part of the broader Steps Against the Burden of Parkinson's Disease project (CT-IDs: 6ef2e427b002, 6ef2e427b003, 6ef2e427b004), comprising three harmonised but independently conducted RCTs. All sites follow a shared core protocol, allowing fo

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Diagnosis of PD according to the MDS Criteria 2. Hoehn and Yahr stages I to III; 3. Movement Disorder Society-sponsored version of the Unified Parkinson Disease Rating Scale (MDS-UPDRS) gait sub-score of 1 or more 4. Signed informed consent to participation Exclusion Criteria: * Any known general health condition likely to interfere with or to pose a contraindication to non-medically supervised physical exercise. * Moderate or severe depression (BDI-II ≥18) * Cognitive impairment which may preclude the possibility to provide a fully informed consent to enrolment. * Linguistic comprehension capacity less than 75% in ordinary conversation * Severe psychiatric comorbidity which may interfere with compliance to the study protocol * History of or current status of substance dependency * Unable to walk less than 1 floor * Thoracic pain in the last 4 weeks * Currently enrolled in other interventional studies * Implanted Deep Brain Stimulation device
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What it tests

  • Exercise
  • Exercise
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Where

1 site
Neuroscience Research Australia
Randwick, Australia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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