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Study of the Intestinal Microbiota

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Rouen
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In plain words

What the trial is, and whether it could suit you

The intestinal microbiota is the set of numerous microorganisms (between 1012 and 1014 bacteria, viruses, parasites, and non-pathogenic fungi) that live in our digestive tract, mainly in the small intestine and colon. Like a fingerprint, the intestinal microbiota is unique to each individual. However, there is a common core of 15-20 species present in all humans, responsible for the essential functions of the microbiota. Recent techniques for high-throughput sequencing of genetic material and metabolomics (i.e., the global analysis of the elements produced by the microbiota) have made it possible to more precisely describe the relationships between microorganisms and the host and how each influences the functioning of the body. Thus, we now know that the microbiota plays a role in digestive, metabolic, immune, and neurological functions. Certain events will modify the microbiota in a mo

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📋 Eligibility rules (as published)
Inclusion Criteria: Brain-injured patient group: Any adult patient admitted to neurosurgical or surgical intensive care for severe brain injury, traumatic or not, requiring intubation, eligible for indirect calorimetry measurements, and whose expected length of stay is \> 48 hours. Control group: Any adult patient admitted to surgical intensive care for multiple trauma without associated brain injury and/or for shock (hemorrhagic or septic\*) and whose expected length of stay is \> 48 hours. Exclusion Criteria: * Refusal to participate in the study (request of non-opposition from relatives if the patient is unfit) * Lack of social security affiliation; * Minor patient; * Patient under legal protection (guardianship or guardianship); * Pregnant woman; * Moribund patient or whose expected length of stay is ≤ 48 hours; * Contraindication to indirect calorimetry (high FiO2, etc.);
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What it tests

  • Not listed
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Where

1 site
Services de Réanimation Chirurgicale Et Réanimation Neurochirurgicale
Rouen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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