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Mic Mac: Micro- and Macrocirculatory Assessment During Cardiac Surgery in Patients at Risk of Vasoplegic Syndrome: A Prospective Study.

Recruitingn/aAges 18 Years - anyAllEuropean Georges Pompidou Hospital
NCT07059715 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This research focuses on understanding the vasoplegic syndrome after cardiac surgery under extracorporeal circulation and in the aftermath of your surgery in the ICU. The investigators evaluate variations in a number of clinical and biological parameters during cardiac surgery and in the 48 hours following resuscitation. In addition to all the monitors investigators usually use to monitor vital parameters during this type of procedure, investigators use sensors placed on the skin at the earlobe and palm of the hand to assess the quality of blood circulating in the body. The investigators would like to know if these observations help us to better understand the vasoplegic syndrome (persistent drop in blood pressure requiring the administration of medication to maintain normal blood pressure), a known but poorly understood complication following cardiac surgery under extracorporeal circu

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📋 Eligibility rules (as published)
Inclusion Criteria: Have at least 3 point of the following risk factors for post-body circulation vasoplegic syndrome: * Acute or chronic heart failure with left ventricular ejection fraction\< 40% (1 pt) * Complex cardiac surgery ( 2 pts) * Cardiovascular risk factors with a EuroSCORE\> 4% (1 pt) * Chronic Kidney Disease Stage 4 * Type 2 Diabetes Mellitus * Pre-operative heparin treatment * Hypothyroidism * Anti-hypertensive treatments including an ACE inhibitor, an angiotensin II receptor antagonist, a beta-blocker or Sacubitril Exclusion Criteria: * Heart transplantation * Pre-operative hemodynamic instability * Pregnant women * Age \<18 * Pre-existing sepsis * Extracorporeal circulation support * Heartmate/Impella/Carmat patient * Hypothalamo-hypophyseal pathologies * Adrenal insufficiency * Anuric patient * Guardianship/ curatorship * Lack of social security coverage * Opposition to clinical research by patients or their families
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What it tests

  • Not listed
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Where

1 site
Georges Pompidou European Hospital
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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