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Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients

RecruitingNAAges 18 Years - 65 YearsAllCeren Derya Gültekin
NCT07061444 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Introduction: After haematopoietic stem cell transplantation (HSCT), patients often experience complications such as respiratory difficulties, fatigue and decreased quality of life. The aim of the study was to compare the effectiveness of different inspiratory muscle training (IMT) protocols on respiratory muscle strength and endurance, dyspnoea, maximal exercise capacity, diaphragmatic function, respiratory function parameters, peripheral muscle strength, fatigue, quality of life, oxidative stress parameters, muscle biomarkers and inflammatory biomarkers in HSCT recipients during the transplantation process. Method: The study will include patients between 18-65 years of age, who are able to walk and understand the instructions, who do not have orthopedic, neurological or cardiac disorders and who will undergo haematopoietic stem cell transplantation. Patients with cognitive impairment

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📋 Eligibility rules (as published)
Inclusion Criteria: * Planned haematopoietic stem cell transplantation in the adult bone marrow transplant unit * Between the ages of 18-65 * Under standard medical treatment, including immunosuppressives, antibiotics and other medications * Ability to walk, co-operate and be clinically stable * No history of orthopaedic, neurological, cardiac disorders Exclusion Criteria: * Cognitive disorders * Have orthopaedic or neurological diseases that may affect the assessment of physical fitness tests * Having comorbidities such as asthma, COPD * Conditions in which exercise training is contraindicated, such as acute bleeding, haemoglobin value \<5 g/dl, platelet count ≤10000 mm3, high fever (body temperature \>38◦C), severe pain, confusion, dizziness, nausea and vomiting * Patients with pneumonia or any acute infection -≥ 3 consecutive sessions of interruption of the exercise group subjects' attendance to the training protocol * Loss of willingness to participate in the research during the research process * Development of clinical haemodynamic instability in patients
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What it tests

  • Inspiratory Muscle Training
  • Functional Inspiratory Muscle Training
  • Sham Inspiratory Muscle Training
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Where

1 site
Istinye University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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