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Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

RecruitingNAAges 18 Years - 65 YearsFemaleTanta University
NCT07062367 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will be conducted to evaluate the effects of different anesthetic modalities \[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age from 18 to 65 years. * American Society of Anesthesiologists (ASA) physical status I and Ⅱ. * Body mass index (BMI) ≤35. * Females scheduled for laparoscopic hysterectomy. Exclusion Criteria: * Patients' refusal to participate in the study. * Hypersensitivity and allergy to drugs of the study. * Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery * Any central nervous system or cardiovascular disease, severe hepatic or renal impairment * Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery * If peak inspiratory pressure (PIP) exceeds 35.
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What it tests

  • Propofol
  • Sevoflurane plus lidocaine infusion
  • Sevoflurane
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Where

1 site
Tanta University
Tanta, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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