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The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers

RecruitingNAAges 18 Years - 35 YearsAllWageningen University
NCT07062562 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years). The main questions to answer are: * Does whole-body NMES followed by protein intake improve muscle protein synthesis rates during 3 days of bed rest? * Does repeated NMES sessions offer protective effects on muscle mass and function during extended periods of inactivity? Researchers will compare sham electrical electrostimulation, electrical stimulation and electrical stimulation + protein groups to see if whole-body electrostimulation combined with protein intake offers the greatest improvement in muscle protein metabolism and muscle preservation. Participants will: * Undergo 3 days of bed rest while receiving one of the following interventions: * Sham-NMES followe

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged from 18-35 years * 18.5 \< BMI \< 30 kg·m2 * Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes) Exclusion Criteria: * Employed or undertaking a thesis or internship at the department of Human and Animal Physiology at Wageningen University * Smoking * Diabetes (Type 1, Type 2, or genetic form of diabetes) * Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic) * Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) * Known allergy to lidocaine * Prone to keloid forming (i.e. hyperplastic growth of scars) * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis) * Regular use of dietary protein and/or amino acid supplements (\>3 times per week) * Currently involved in a structured progressive resistance training programme (\>3 times per week) * A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia * Any previous motor disorders or disorders in muscle and/or lipid metabolism * Any back, leg, knee, neck, shoulder or postural complaints * Presence of an ulcer in the stomach or gut and/or strong history of indigestion * Contra-indications for DXA scans (e.g. undergoing radiologic examination) * Lactose intolerance * Known severe kidney problems * Pregnant or breastfeeding * Unable to give consent
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What it tests

  • Sham (No Treatment)
  • NMES
  • Protein bolus (20g)
  • Standard nutrition
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Where

1 site
Wageningen University
Wageningen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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