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Cryocompression for CIPN

RecruitingNAAges 18 Years - anyAllDana-Farber Cancer Institute
NCT07064798 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the effectiveness, tolerability, and safety of using cooling therapy and pressure (cryocompression) to reduce peripheral neuropathy, a condition affecting the nerves supplying the arms and legs (limbs) resulting in possible numbness, pain, and/or loss of motor function, that may occur as a result of taxane-based chemotherapy. The name of the device used in this research study is: -Paxman Limb Cryocompression System (PLCS)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults \> 18 years of age * Gynecologic or breast malignancy * Starting 1st cycle of treatment with chemotherapy regimens: * Weekly paclitaxel x 12 or weekly paclitaxel/carboplatin x 12, Q2 weeks paclitaxel X4 (preceded by doxorubicin/cyclophosphamide). (Breast Oncology) * Q3 weeks paclitaxel/carboplatin X 6-8 (GYN) * Receiving treatment on the main campus of DFCI (these patients are currently seen on Yawkey 9 and 10 and at Chestnut Hill) * Able to complete questionnaires in English or Spanish Exclusion Criteria: * Previous exposure to neurotoxic chemotherapy * Pre-existing neuropathy * History of Raynaud's phenomenon, cold agglutinin disease, cryoglobulinemia, cryofibrinogenemia, post-traumatic cold dystrophy, peripheral arterial ischemia, or sickle cell disease * Undergoing desensitization * Lymphedema in the limb where the device would be applied * Open skin wounds or ulcers of the limbs where the device would be applied
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What it tests

  • Paxman Limb Cryocompression System
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Where

1 site
Dana-Farber Cancer Institute
Boston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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