🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity

RecruitingEARLY Phase 1Ages 40 Years - 80 YearsAllThe University of Hong Kong
NCT07065591 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Obesity is associated with increased pain with knee osteoarthritis and increase progression of knee osteoarthritis while weight loss intervention has been shown to reduce pain and requirement of total knee replacement. In this study, the investigators will assess using diet modification with exercise, and metformin, a common, safe, diabetes mellitus medication that has been in use for 70 years to achieve better weight control to reduce knee pain. This helps the investigators to understand whether the combined treatment can reduce joint pain, reduce body weight and improve symptoms and requirement of total knee replacement.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women age between 40 and 80 years old, with overweight or obesity (body mass index ≥23 kg/m2) according to Hong Kong Centre for Health Protection definition of overweight and obesity. * Knee pain for 6+ months with Visual Analogue Scale (VAS) \> 40mm/100mm and * Meet the American College of Rheumatology criteria for knee OA * OA referred for consideration for joint replacement Exclusion Criteria: * Severe radiographic knee OA (Kellgren-Lawrence grade 4) or severe knee pain (VAS\>80mm/100 mm) that could not tolerate further conservative management; * inflammatory arthritis like rheumatoid arthritis, crystal arthritis, etc. * Preexisting diabetes on antidiabetic drug or drug allergy to metformin. * Recent knee surgery of the same knee * Significant bone loss. * Concomitant neuromuscular diseases affecting lower limb function. * renal or liver impairment precluding use of metformin. * VitaminB12 deficiency
💊

What it tests

  • Metformin
  • Placebo
📍

Where

1 site
Maclehose Medical Rehabilitation
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy