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The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing

RecruitingNAAges 18 Years - anyAllLarissa University Hospital
NCT07066566 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing. Participants will : 1. receive NHF via both interfaces (FiOโ‚‚ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed. 2. baseline characteristics will me monitored throughout the interventions 3. Esophageal pressure and minute ventilation will be monitored.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. age โ‰ฅ18 years old 2. absence of symptoms and signs of respiratory failure (SpO2\>95% at FiฮŸ2 0.21) Exclusion Criteria: 1. pregnancy 2. SpO2\<94% at FiฮŸ2 0.21 3. neuromuscular disease 4. contraindications to esophageal pressure monitoring (e.g., uncontrolled coagulopathy, esophageal disease, nasal trauma, allergy to local lidocaine)
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What it tests

  • Asymmetric nasal cannula - DUET
  • Conventional nasal high flow cannula
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Where

1 site
University Hospital of Larissa, Department of Pulmonary Medicine
Larissa, Greece
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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