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Suppressive Functions of Regulatory T Cells in Migraine

RecruitingNAAges 18 Years - 50 YearsFemaleUniversity Hospital, Clermont-Ferrand
NCT07067112 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases. Cytokine and immune cell dysregulations have been evidenced in migraine. Inflammation seems to play an important role in migraine chronification; however, the inflammatory mechanisms involved in migraine pathophysiology remain unclear. Regulatory T (Treg) cells play a central role in maintaining immune homeostasis. They regulate effector T (Teff) cell proliferation and cytokine production, through several suppressive mechanisms, such as the hydrolysis of adenosine triphosphate (ATP) into adenosine (ADO), mediated by surface enzymes Cluster Differentiation 39 (CD39) and Cluster Differentiation 73 (CD73). ATP is involved in pain processes in migraine, and insufficient hydrolysis could participate in

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📋 Eligibility rules (as published)
Inclusion Criteria: * Females * 18 to 50 years old * For chronic migrain : At least 8 monthly migraine days Exclusion Criteria: * BMI \< or = 17kg/m² or \> or = 30kg/m² * Diagnosis or suspicion of type 2 diabetes, auto-immune or inflammatory diseases, immunodeficiency diseases * Diagnosis of headache of non-migraine origin, except for tension type headache (i.e.: cluster headache, post-traumatic headache, cerebral tumour…) * For controls participants : tension type headache with 4 or more monthly headache days * Pregnancy, delivery, miscarriage, breastfeeding, participation in a medically assisted human reproduction program (ovary stimulation/hormone therapy) \< 3 months before blood sampling * Menopause, hysterectomy, or bilateral oophorectomy * Modification of prophylactic anti-migraine therapy (start, change of molecule, interruption) \< 1 month before blood sampling (for migraine participants) * Hormone therapy (beside contraception and treatment of endometriosis) * Transplantation (solid organ or bone marrow) * Cancer (active or remitting) \< 1 year before blood sampling (solid organ or blood) * Haematologic disease (benign or malignant) of the lymphoid lineage * Guardianship, curatorship, safeguard of justice or deprivation of liberty * For controls : history of migraine
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What it tests

  • Blood sampling, questionnaire and phone call
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Where

1 site
CHU Clermont-Ferrand
Clermont-Ferrand, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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