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Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease

RecruitingNAAges 18 Years - 80 YearsAllChulalongkorn University
NCT07067229 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participants aged between 18 and 80 years * Diagnosed with any type of motor neuron disease (MND) * Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3 Exclusion Criteria: * History of other neurological disorders, such as stroke * Use of ventilatory support * Severe dementia
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What it tests

  • Personalized rTMS
  • Standard rTMS
  • Sham rTMS
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Where

1 site
King Chulalongkorn Memorial hospital, The Thai Red Cross Society
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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