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Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols

RecruitingNAAges any - anyAllNational and Kapodistrian University of Athens
NCT07077122 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures. Despite the fact that periodontal bacteria are etiological agents, host susceptibility related to the inflammatory response to plaque bacteria is the main determinant of the development of periodontitis. Non-surgical periodontal therapy (NSPT) represents the base of any therapeutic approach. Its main component is the removal of bacterial deposits, i.e. soft biofilm or mineralized calculus, from the tooth surface via mechanical debridement. It is well established that patients suffering from periodontitis present with a low-grade systemic inflammatory state when compared to healthy subjects. Increased concentrations of inflammatory biomarkers in systemic circulation, such as, C-reactive protein (CRP) and interleukin (IL)-6, have already been reported.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Periodontitis stage III or IV * Non-smokers or light smokers (\<10 cigarettes/day) * No NSAIDs in regular basis or antibiotics 3 months before * No previous periodontal treatment 12 months before * No presence of other acute or chronic infections * No systemic disease or medication known to affect the serum level of inflammatory markers (cyclooxygenase inhibitors, platelet aggregation inhibitors, lipid lowering agents, â-adrenoreceptor antagonists, angiotensin converting enzyme inhibitors, antidiabetic agents, estrogen-based medications, medication for autoimmune disease, magnesium or vitamin E supplements) * No pregnancy or lactation * Written informed consent.
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What it tests

  • Scaling and Root Planing
  • antibiotic prophylaxis
  • 810nm Diode Laser
  • Air Polishing
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Where

1 site
Department of Periodontology, Dental School of Athens
Athens, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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