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โ† Trials
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Natriuresis-guided Depletion After Cardiac Surgery

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire, Amiens
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In plain words

What the trial is, and whether it could suit you

Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical. Recent data suggest that natriuresis-guided furosemide titration using point-of-care urinary sodium sensors (LAQUAtwin NA-11, Horiba) may improve the efficiency and safety of fluid removal, but no randomized trial has yet evaluated this approach in postoperative cardiac surgery patients Our goal is to assess the clinical impact, safety, and feasibility of a natriuresis-guided furosemide protocol after cardiac surgery requiring cardiopulmonary bypass.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adult patient (age \> 18 years) * Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures * Undergoing surgery with cardiopulmonary bypass (CPB) * Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician * Written and oral informed consent obtained * Covered by the French national health insurance (Sรฉcuritรฉ Sociale) Exclusion Criteria: * Aortic arch repair requiring deep hypothermic circulatory arrest * Active endocarditis * Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin) * Failure to wean from CPB requiring mechanical circulatory support * Chronic kidney disease with an estimated glomerular filtration rate (eGFR) \< 60 mL/min * Chronic use of loop diuretics * Known allergy to furosemide * Active postoperative bleeding and/or reoperation for bleeding * Participation in another interventional study that may affect the primary outcome measure * Patient deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curatorship)
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What it tests

  • Furosemide intravenous titration based on natriuresis
  • Furosemide intravenous titration based on clinical examination
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Where

1 site
CHU Amiens Picardie
Amiens, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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