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โ† Trials
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Teclistamab in Newly Diagnosed Mayo Stage IIIB AL Amyloidosis

RecruitingPhase 2Ages 18 Years - anyAllPeking Union Medical College Hospital
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In plain words

What the trial is, and whether it could suit you

This is a phase II study in patients with newly diagnosed Mayo stage IIIB immunoglobulin light-chain (AL) Amyloidosis to evaluate the efficacy and safety of teclistamab

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Biopsy confirmed AL amyloidosis * Mayo 2004 stage IIIB * dFLC โ‰ฅ 50mg/L Exclusion Criteria: * Co-morbidity of uncontrolled infection * Co-morbidity of other active malignancy * Co-diagnosis of multiple myeloma or waldenstrom macroglobulinemia * Co-morbidity of grade 2 Mobitz II or grade 3 atrioventricular block (expect for those with implanted pacemaker) * Co-morbidity of sustained or recurrent nonsustained ventricular tachycardia * Seropositive for human immunodeficiency virus * Hepatitis B virus (HBV)-DNA \> 1000 copies/mL * Seropositive for hepatitis C (except in the setting of a sustained virologic response) * Neutrophil \<1ร—10E9/L, hemoglobin \< 8g/dL, or platelet \< 75ร—10E9/L. * Severely compromised hepatic or renal function: alanine transaminase (ALT) or aspertate aminotransferase (AST) \> 5 ร— upper limit of normal (ULN), total bilirubin \> 2 ร— ULN, estimated glomerular filtration rate \< 20 mL/min, or receiving renal replacement therapy
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What it tests

  • Teclistamab (Tec)
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Where

1 site
Peking Union Medical College Hospital
Beijing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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