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Study of the Pathophysiological Mechanisms Involved in the SAPHO Syndrome: Genetic Component and Immune Response

Recruitingn/aAges 18 Years - anyAllFondation Hôpital Saint-Joseph
NCT07081880 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a chronic inflammatory rheumatism associating bone or joint lesions and dermatological manifestations dominated by severe acne and palmar and palmoplantar pustulosis. Prevalence of SAPHO syndrome is estimated at 1/50000 in France, but this figure is probably underestimated due to frequent misdiagnosis. Osteoarticular manifestations form a rheumatic picture very similar to that of other forms of spondyloarthritis (SpA). The latest French recommendations do not distinguish SAPHO syndrome from other forms of SpA. As a result, the management of SAPHO remains fairly heterogeneous, essentially based on the local experience of rheumatologists. Delays in diagnosis and difficulties in finding effective treatment can result in significant disability and reduced quality of life, particularly detrimental in a young population

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient aged ≥ 18 years * Patient diagnosed with SAPHO syndrome * Weight \> 35 kg * Patient affiliated with a health insurance plan * French-speaking patient * Patient who has given free, informed, and written consent Exclusion Criteria: * Patient under guardianship or curatorship * Patient deprived of liberty * Patient under legal protection * Pregnant or breastfeeding patient
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What it tests

  • biological sampling
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Where

2 sites
Hôpital Cochin
Paris, France
Hôpital Paris Saint Joseph
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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