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Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

Recruitingn/aAges 50 Years - anyFemaleUConn Health
NCT07083531 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female of African Decent. * Age 50 years or older. * Lack of menstrual period for at least 12 consecutive months Exclusion Criteria: * Taking medications known to influence bone metabolism (e.g., glucocorticoids, hormonal therapy, cancer or chemotherapy meds, anti-resorptive medications or anabolic therapies). * Known metabolic bone disorder (e.g., uncontrolled thyroid disease, hyperparathyroidism, Vitamin D deficiency) * Taking an investigational drug * Documented sickle cell disease
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What it tests

  • Healthy volunteers without SCT
  • Healthy volunteers with SCT
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Where

1 site
UConn Health
Farmington, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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