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Dehydration, Rehydration, and Impact on Physiology

RecruitingNAAges 45 Years - 65 YearsAllTexas Tech University
NCT07084675 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65. Aim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs. Aim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance. Participant will: complete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol. attend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyrat

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📋 Eligibility rules (as published)
Inclusion Criteria: * Apparently Healthy * BMI \< 30 kg/m2 * Body weight is at least 110 lbs Exclusion Criteria: * Currently pregnant * Have Type 1 Diabetes or Type 2 Diabetes * Have chronic kidney disease or a history of kidney stones * Have hypertension * Take medications that can cause fluid retention, such as corticosteroids, chronic use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Hormonal Therapies (e.g., estrogen, androgens or anabolic steroids), Antihypertensives, Psychiatric Medications (e.g., Lithium), Vasodilators * Take medications that reduce fluid retention: diuretics, and RAAS Inhibitors (e.g., ACE inhibitors and ARBs)
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What it tests

  • Hydration-Dehydration-Rehydration Protocol (HDR)
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Where

1 site
Texas Tech University
Lubbock, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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