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โ† Trials
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Natural History Study of Inherited Retinal Diseases

Recruitingn/aAges any - anyAllZhongmou Therapeutics
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In plain words

What the trial is, and whether it could suit you

This prospective, observational investigation seeks to delineate the interplay between chromatic vision deficits and both functional visual outcomes and anatomical retinal biomarkers in individuals affected by Inherited Retinal Dystrophies (IRDs). The study will recruit approximately 200 subjects, encompassing a heterogeneous population of IRD patients-spanning a range of genotypes and clinical severities-as well as control participants devoid of retinal pathology. All enrolled individuals will undergo a standardized battery of evaluations, including quantitative color vision assessment, best-corrected visual acuity (BCVA) determination, and advanced multimodal retinal imaging. The principal aim is to characterize the relationship between impairments in color discrimination and morphologic disruptions within the outer retinal layers, with particular emphasis on the continuity and reflec

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Color Perception and Communication Ability Participants must have the ability to verbally identify or describe colors and test stimuli. This requires adequate cognitive and communicative capacity to understand instructions and respond appropriately during color vision testing. 2. Diagnosis of Inherited Retinal Dystrophy (IRD Group Only) Participants assigned to the IRD group must have a confirmed clinical diagnosis of an inherited retinal dystrophy 3. No Evidence of Inherited Retinal Disease (Control Group Only) Participants in the control group must have: * No known history or clinical evidence of inherited retinal degeneration * Normal retinal health or only non-retinal ocular conditions not affecting retinal function (e.g., mild cataract, corrected refractive error) * Normal or expected-normal color vision Exclusion Criteria: 1. Non retinal causes of color vision loss * Optic neuropathies (e.g., optic neuritis, glaucoma related optic nerve damage) * Cortical vision impairments affecting color perception * Any other neurological or optic nerve pathology causing color vision deficiency 2. Psychological or cognitive conditions affecting color perception or communication * Severe developmental delays * Cognitive impairments interfering with ability to comprehend or reliably perform color vision tests * Psychiatric conditions that impair visual interpretation or reliable testing 3. Prior treatment with potential transient effects on the retina * Recent retinal surgery * Recent drug therapy affecting retinal structure or function * Any acute intervention that might confound the correlation analyses due to lack of a stable baseline
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What it tests

  • Not listed
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Where

1 site
Renmin Hospital of Wuhan University
Wuhan, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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