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ROS-Scavenging Nanozyme Combined With Thermotherapy Alleviate Radiation Dermatitis in Patients With Head and Neck Cancer

RecruitingNAAges 18 Years - 80 YearsAllWest China Hospital
NCT07086638 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Severe radiation dermatitis remains a challenging complication in head and neck cancer with limited treatment options; this study aims to evaluate a novel Prussian blue-based nanozyme combined with near-infrared thermotherapy to promote effective healing of Grade III lesions.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with a pathological diagnosis of non-metastatic head and neck malignant tumors; 2. Patients deemed suitable for high-dose radiotherapy, either as a primary treatment or as postoperative treatment following surgical resection. Exclusion Criteria: 1. Eastern Cooperative Oncology Group performance status of \>2; 2. Pre-existing skin rash, ulceration or open wound in the treatment area; 3. Known allergy to trolamine or prussian blue; 4. Inflammatory or connective tissue disorder of the skin; 5. History of head and neck radiotherapy.
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What it tests

  • Photo-responsive nanozyme
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Where

1 site
Sichuan University West China Hospital
Chengdu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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