Window Prophylaxis for Pediatric Tuberculosis Prevention Trial

Inclusion Criteria: * Household contacts of patient (index case) with a new diagnosis of microbiologically confirmed pulmonary tuberculosis * Age ≥5 to \<18 years old Exclusion Criteria: * Suspected active tuberculosis in initial assessment (clinical or radiological) * Current pregnancy or breastfeeding * Immunocompromised * Allergy or contraindication to isoniazid or rifapentine * Chronic liver disease or alcohol use disorder * History of previous treatment for active or latent tuberculosis infection * Previous tuberculin skin test * Household contacts of a tuberculosis index patient with a known or suspected drug-resistant M. tuberculosis strain * Household contacts or a tuberculosis index patient currently living away from home for more than four weeks * Household contacts of a tuberculosis index patient who have already received more than 15 daily doses of antituberculous treatment