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Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Recruitingn/aAges 18 Years - anyAllPeking University First Hospital
NCT07088874 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years; * Scheduled to undergo unilateral radical nephrectomy. Exclusion Criteria: * Solitary kidney; * Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \<30 mL/min/1.73m²); * Tumor invasion of the vena cava requiring thrombectomy; * Other conditions deemed by the investigator as unsuitable for participation in this study.
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What it tests

  • Not listed
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Where

1 site
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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