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Cocaine Cue-reactivity Incubation Study

RecruitingNAAges 18 Years - 65 YearsAllIcahn School of Medicine at Mount Sinai
NCT07091877 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this study, the research team proposes to longitudinally assess incubation of cue-reactivity, its reduction with cognitive reappraisal (CR; a self-regulation technique) and examine the impact of CR on clinical outcomes in individuals with cocaine use disorder (CUD). The primary objective is to use psychophysiological markers for tracking brain activity and behavior and changes therein with the use of CR during abstinence in CUD. The secondary objective is to examine whether brain and behavioral changes are associated with clinical outcomes in individuals with CUD. The primary endpoint is the time-related change in brain and behavioral indices with CR during abstinence in individuals with CUD. The secondary endpoint is the impact of CR-mediated changes on clinical outcomes of individuals with CUD. In this 5-yearlong study the research team will recruit 252 individuals seeking-treatmen

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ability to understand and give informed consent * Age 18-65 * DSM-5 Diagnosis of CUD (Cocaine Use Disorder) * Have appropriate abstinence duration (i.e., \<2 months) at the first visit. * Must be seeking treatment for CUD (at the first visit) Exclusion Criteria: * DSM-5 diagnosis for other psychiatric illnesses (other than mood and anxiety disorders that are highly comorbid with substance use disorders) * Urine positive for any psychoactive drugs (e.g., cocaine, methamphetamine, cannabis, opiates, benzodiazepines, etc.) at baseline * Head trauma with loss of consciousness * History of neurological diseases, including seizures * Thick and/or non-removable hair braids that present difficulty for EEG electrode-scalp contact
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What it tests

  • Cognitive Reappraisal
  • Control cue-reactivity task
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Where

1 site
Icahn School of Medicine at Mount Sinai
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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