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Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study

RecruitingNAAges any - anyAllART Fertility Clinics LLC
NCT07093619 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In assisted reproductive technology (ART), sperm preparation aims to select the most viable sperm for ICSI. Unlike conventional methods like density gradients or sperm washing, microfluidic techniques mimic natural selection in the female reproductive tract by using laminar flow without centrifugation, reducing the risk of DNA damage. This method isolates highly motile sperm while filtering out debris and immotile cells. Studies show that microfluidics improve embryo quality, increase pregnancy rates, and may lead to higher euploidy rates. Additional benefits include improved safety, scalability, and shorter preparation times.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Women with at least 8 MII per cycle after denudation (AFC≥8). 2. Women of all ages. 3. All embryo qualities ≥BL3CC at the time of biopsy on day 5, 6 and/or 7. 4. Fresh sperm used from ejaculate with a concentration ≥1 mill/ml and ≥10% motility (A+B). 5. Sperm samples with a minimum of 2 ml. Exclusion Criteria: * Frozen oocytes samples with severe oligospermia (≤1mill/ml). * PGT-M cases * Sperm with \> 1M/ml of round cells
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What it tests

  • FERTILE Plus
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Where

1 site
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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