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Mentalization Based Treatment (MBT) in Help Seeking Youths With a Clinical High-Risk Condition for Psychosis (CHR-P)

RecruitingNAAges 14 Years - 30 YearsAllMarco Armando
NCT07093671 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective of this study is to evaluate the efficacy of Mentalization-Based Treatment (MBT) combined with Need-Based Clinical Interventions (NBCI) compared to NBCI alone, on CHR-P diagnostic statuses and symptom expression (Hypothesis 1). Specifically, the investigator will assess diagnostic outcomes using a 3-level variable: transition to psychosis, CHR-P status quo, and remission out of CHR-P, as well as CHR-P symptom expression. The investigator hypothesize that: (1a) the experimental treatment (MBT + NBCI) will have a significant effect on diagnostic status (i.e. transition to psychosis) at the end of treatment and follow-up; (1b) the experimental treatment (MBT + NBCI) will significantly reduce the severity of psychotic symptoms at the end of treatment and follow-up.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 14-30 years with a CHR-P condition, as defined by the SIPS criteria * Patients who provide informed consent Exclusion Criteria: * Patients with a prior diagnosis of a psychotic disorder * Intellectual disability (IQ \< 70). * Patients whose psychotic symptoms are primarily induced by substance misuse. * Patients with significant language barriers * Parents/legal authority who do not provide informed consent (only minors) * Adult patient under guardianship Note: Comorbidities with other psychiatric disorders (e.g., Autism Spectrum Disorder, Personality Disorders) will not constitute an exclusion criterion.
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What it tests

  • MBT + NBCI
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Where

1 site
CHUV
Lausanne, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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