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Immunoglobulins in Multiple Myeloma Patients Receiving a BCMA-Directed T Cell Engager

RecruitingPhase 4Ages 18 Years - anyAllCHU de Quebec-Universite Laval
NCT07094048 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Bispecific antibody therapies targeting BCMA (B-cell maturation antigen) represent a novel therapeutic approach for patients with multiple myeloma. They are currently used in cases of refractory multiple myeloma but are also being investigated in earlier lines of treatment. However, these new therapies can lead to deeper immunosuppression and exacerbate an underlying immunosuppressive state in patients with multiple myeloma. As a result, infectious complications are common with these therapies and are a significant concern. Therefore, preventing infections in this population is crucial. However, data on the best strategies for prevention are currently lacking.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Multiple myeloma patient: * ≥ 18 years old * ≥ 1 prior lines of therapy * Receiving a BCMA-directed T-cell Engager therapy (starting on treatment) * On previous Ig support or not Exclusion Criteria: * Less than 18 years old * Pregancy or breastfeeding
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What it tests

  • Target trough IgG level of 8-10 g/L
  • Target trough IgG level 4-6 g/L
  • No history of recurrent or severe infections and total IgG level higher or equal at 4 g/L
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Where

2 sites
Santé Québec Chaudière-Appalaches
Lévis, Canada
Centre Intégré de Cancérologie
Québec, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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