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High-Titer Neutralizing Plasma for West Nile Fever in Hospitalized Patients

RecruitingPhase 2Ages 18 Years - anyAllGili Regev-Yochay MD
NCT07094724 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will test whether plasma containing high levels of neturalizing antibodies against West Nile virus (WNV) can help people hospitalized with severe West Nile fever recover faster and avoid serious complications. West Nile virus is spread by mosquitoes and can cause mild flu-like symptoms or, in severe cases, brain infections. Currently, there is no specific medication to treat the infection, and doctors primarily provide supportive care. In this study, patients who are sick enough to require hospitalization will receive plasma donated by people who have recovered from West Nile virus and developed high titer neutralizing antibodies against the disease. Researchers will closely monitor these patients to see how quickly their symptoms improve and whether the plasma helps reduce the risk of death or shorten hospital stays. To evaluate how well the plasma works, researchers will c

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults hospitalized due to WNF, confirmed by a positive IgM or PCR result in blood or cerebrospinal fluid (CSF). * Symptomatic acute illness, including fever and/or neurological manifestations (headache, somnolence, confusion, seizures, personality changes, extra-pyramidal manifestations, cranial nerve palsies, etc.). * No more than 72 hours have elapsed since collection of diagnostic sample. * Age criteria * Age ≥60 years OR * Age 18-59 years with previously documented immunosuppression, including hypogammaglobulinemia, treatment with anti-CD20 agents during the last 12 months, hematologic malignancy, bone marrow transplantation, solid organ transplantation, acquired immunodeficiency syndrome (AIDS), or severe primary immunodeficiency. Exclusion Criteria: * Age \<60 years without significant immunosuppression. * More than 72 hours have elapsed since collection of diagnostic sample. * Pregnancy.
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What it tests

  • Plasma
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Where

1 site
Sheba Medical Center
Ramat Gan, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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