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Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D

RecruitingNAAges 20 Years - 40 YearsMaleBangladesh Medical University
NCT07096414 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is an experimental study (interventional self-controlled trial, pretest-post test design). The goal of this clinical trial is to evaluate the effect of vitamin D3 supplementation on quantitative EEG in male epileptic patients with hypovitaminosis D. . The main question it aims to answer is: Vitamin D3 supplementation has effect on brain waves in male epileptic patients with hypovitaminosis D. Researcher will compare the effect of Vitamin D3 supplementation on brain waves in male epileptic patients with hypovitaminosis D with their pre-intervention (baseline) condition on brain waves to assess whether there will be any improvement of brain electrical activity by quantitative electroencephalogram (QEEG). Participants will: Take Vitamin D3 orally for 8 weeks (50,000IU/week) Visit the medical university after 8 weeks for evaluation of serum 25 (OH) D level and quantitative electroe

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed male patients with Epilepsy by neurologist from the Out Patient Department of Department of Neurology, BMU by taking proper history of at least two unprovoked (or reflex) seizures occurring \> 24 hours apart, from patients and eye witnesses. * Hypovitaminosis D (\<30 ng/ml) * BMI : 20 - 24 kg/m² * On antiepileptic medication for 6 months to 2 years (enzyme inducing AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital) * Without any medication that affect central nervous system other than antiepileptic drugs (Antidepressants, Antipsychotic, Anxiolytic, Anesthetic drugs) * Apparently normal physical health Exclusion Criteria: * Patients suffering from absence seizure * Certain AEDs (Sodium valproate, Ethosuximide, Oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam) * Smoker * Alcoholic * Known hypersensitivity to vitamin D3 * Patients with hypertension * Patient with Thyroid disorder * Patient with Diabetes mellitus * Patient with Renal Disease * Patient with liver Disease * Patient with hypercalcemia
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What it tests

  • Vitamin D3
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Where

1 site
Bangladesh Medical University
Dhaka, Bangladesh
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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