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A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy

RecruitingPhase 2Ages 18 Years - 75 YearsAllClimb Bio, Inc.
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In plain words

What the trial is, and whether it could suit you

To evaluate the safety and tolerability of three dose regimens of budoprutug in subjects with PMN

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Confirmed diagnosis of PMN with positive anti-PLA2R antibodies * CD19+ B cell count ≥40 cells/μL * UPCR ≥2.0 g/g * eGFR ≥35 mL/min/1.73 m² * Stable RAAS inhibitor therapy * Blood pressure \<150/90 mmHg at baseline * Adequate hematologic, hepatic, and renal function * Willing to use effective contraception (both sexes) * Other inclusion criteria may apply Exclusion Criteria: * Secondary Membranous Nephropathy * Rapidly progressive glomerulonephritis or other glomerulopathies * Prior B cell-depleting therapy within 24 weeks * Recent use of immunosuppressants * Active or high-risk infections * History of malignancy * Pregnancy or breastfeeding * Recent major surgery or hospitalization * Other exclusion criteria may apply
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What it tests

  • budoprutug
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Where

38 sites
Climb Bio Investigative Site #110
Denver, United States
Climb Bio Investigative Site #105
Orlando, United States
Climb Bio Investigative Site #108
Atlanta, United States
Climb Bio Investigative Site #106
Indianapolis, United States
Climb Bio Investigative Site #101
Clifton Park, United States
Climb Bio Investigative Site #104
Sherman, United States
Climb Bio Investigative Site# 602
Buenos Aires, Argentina
Climb Bio Investigative Site# 603
Buenos Aires, Argentina

…and 30 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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