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Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training

RecruitingNAAges 18 Years - 30 YearsAllStefano Zaffagnini
NCT07097077 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lower limb injuries represent the majority of sports-related injuries, with knee injuries being among the most common. In particular, anterior cruciate ligament (ACL) injuries are considered highly devastating and career-threatening for both professional and amateur athletes. Current surgical and rehabilitation treatments often fail to provide fully satisfactory short- and long-term outcomes. A very high risk of re-injury exists, especially in younger patients, with up to 35% experiencing a second ACL injury, alongside a significant long-term risk of early knee osteoarthritis. Most ACL injuries are non-contact or indirect contact injuries, implicating biomechanical factors and neuromuscular control as key determinants of injury mechanisms. Recent literature shows that patients suffering a non-contact ACL injury have a higher risk of re-injury compared to those with contact injuries, sug

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients who have undergone anterior cruciate ligament reconstruction surgery at any healthcare facility * Able to understand and consent, adults, who have provided informed consent to participate in the study * Male or female * Age between 18 and 30 years at the time of signing the informed consent * Tegner activity level \> 6 Exclusion Criteria: * History and/or evidence of any neurological disorder or functional impairment; * Evidence of previous surgeries on the lower limb; * Inability to provide informed consent; * Inability to perform the tasks required by the procedure; * Pregnant or breastfeeding women; * Oncology patients; * Contraindications to undergoing MRI examinations.
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What it tests

  • Effect of targeted neuromotor training in patients undergoing ACL reconstruction on the volumetric activation of cerebral cortex regions during fMRI.
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Where

1 site
IRCCS Istituto Ortopedico Rizzoli
Bologna, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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