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Avocado Consumption and Cellular Aging in Breast Cancer Survivors

RecruitingNAAges 40 Years - 65 YearsFemaleInstitut Investigacio Sanitaria Pere Virgili
NCT07097155 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Women with breast cancer are at increased risk of comorbidities and premature mortality, potentially due to accelerated biological aging. Telomere attrition has been proposed as a biomarker of this process, which could be mitigated through interventions targeting behavioral factors such as diet. In recent years, avocado has drawn attention in nutritional research due to its unique nutritional profile. Main objective: To evaluate the effect of consuming one avocado per day on biological aging-measured by telomere length-in breast cancer survivors, compared to a habitual diet (less than two avocados per week). Secondary objectives include changes in telomerase activity and biomarkers of inflammation and oxidative stress. Additional objectives include classical cardiovascular disease markers (glucose metabolism, lipid profile, blood pressure); anthropometric measurements; symptoms of depre

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women diagnosed with primary breast cancer in stages I, II or III; * 40-65 years old at screening; * Cancer treatment (radiotherapy and chemotherapy) completed ≥ 6 months but not more than 10 years at the time of recruitment; * Currently consuming less than 2 avocados per week; * Signed the informed consent letter. Exclusion Criteria: * Metastasis; * Ductal carcinoma or lobular carcinoma in situ; * Breast cancer recurrence; * Cancer diagnosis other than breast cancer or non-melanoma skin cancer; * Body mass index ≥40kg/m2; * Currently pregnant or breastfeeding, or planning pregnancy in the following 6 months; * Allergy to latex; * Unwilling to consume avocado; * Immunodeficiency or HIV-positive status; * Alcohol abuse (\>50g/day); * Unstable use of plant sterols, mineral supplements, use of fibre supplements, fish oil, or antioxidants in the 4 weeks prior to enrolment, or plans to change this during the study; * Currently participating in any other randomized controlled trial; * Difficulty or impossibility of an adequate follow-up; * Inability or unwillingness to give written informed consent or to communicate with study personnel, or illiteracy; * Patients with an acute infection or inflammation (e.g., pneumonia) will be allowed to participate in the study 3 months after recovery.
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What it tests

  • Daily Avocado Consumption
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Where

1 site
Unit for Public Health and Nutritional Epidemiology, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili
Reus, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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