Efficacy and Safety of CD19CD20-CAR.p40-T in B-cell Lymphoma

Inclusion Criteria: 1. Aged between 15 and 75 years old, regardless of gender; 2. Diagnosed with relapsed/refractory B-cell lymphoma according to the 2020 World Health Organization (WHO) diagnostic criteria; 3. Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2; 4. Expected survival time of ≥ 3 months; 5. Confirmation of CD20 expression in tumor cells by flow cytometry/immunohistochemistry; 6. Patients tolerant to CD19 CAR-T cell therapy or those with low CD19 expression; 7. No severe heart, lung, liver, or kidney diseases; 8. Capable of understanding and willing to sign the informed consent form for this trial; 9. No contraindications to peripheral blood apheresis for the subject; 10. Having clearly measurable and evaluable lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 standard; 11. The subject must have received standard first- and second-line treatment regimens; 12. Not having received antibody-based drug treatment within 2 weeks before cell therapy. Exclusion Criteria: 1. History of allergy to any component in the cell product; 2. The following conditions in the blood routine examination: White blood cell count (WBC) ≤ 1×10⁹/L, absolute neutrophil count (ANC) ≤ 0.5×10⁹/L, absolute lymphocyte count (ALC) ≤ 0.5×10⁹/L, platelet count (PLT) ≤ 25×10⁹/L; 3. The following conditions in laboratory tests: including but not limited to, total serum bilirubin ≥ 1.5 mg/dl; serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 2.5 times the upper limit of normal; serum creatinine ≥ 2.0 mg/dl; 4. Patients with heart failure classified as grade III or IV according to the New York Heart Association (NYHA) classification criteria; or left ventricular ejection fraction (LVEF) \< 50% as detected by echocardiography; 5. Abnormal lung function with oxygen saturation \< 92% under room air; 6. Myocardial infarction, cardiac angioplasty or stenting, unstable angina pectoris, or other clinically severe heart diseases within 12 months before enrollment; 7. Grade 3 hypertension with poorly controlled blood pressure despite drug treatment; 8. History of craniocerebral trauma, disturbance of consciousness, epilepsy, severe cerebral ischemia or intracerebral hemorrhagic diseases; 9. Patients with autoimmune diseases, immunodeficiency, or other conditions requiring immunosuppressive agent treatment; 10. Presence of uncontrolled active infection; 11. Previous use of any CAR-T cell product or other genetically modified T cell therapies; 12. Vaccination with live vaccines within 4 weeks before enrollment; 13. Subjects positive for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Treponema pallidum particle agglutination assay (TPPA)/rapid plasma reagin (RPR), as well as HBV carriers; 14. History of alcohol abuse, drug abuse, or mental illness in the subject; 15. The subject participated in any other clinical study within 3 months before joining this clinical study; 16. Female subjects with any of the following conditions: a) Currently pregnant or breastfeeding; or b) Having a pregnancy plan during the trial period; or c) Being fertile but unable to take effective contraceptive measures; 17. Other circumstances that, in the opinion of the investigator, make the subject unsuitable for participation in this study.