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Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)

RecruitingNAAges 18 Years - anyAllInstitut du Cancer de Montpellier - Val d'Aurelle
NCT07098182 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Colorectal cancers and ovarian cancers are respectively the 2nd and 5th cause of cancer mortality in France. Surgical resection is a crucial step in the therapeutic management of colorectal cancers. For advanced ovarian cancers, the objective of cytoreductive surgery is to obtain complete macroscopic resection with no visible residual disease. One or more digestive resections are often required to achieve this goal of complete surgery (usually a modified posterior pelvic exenteration with colorectal resection). A ligation of the inferior mesenteric artery at its origin is classically performed in left colectomies and rectal resection for colorectal cancers. This allows the resection of the colorectal segment with a complete mesocolic lymphadenectomy until the origin of the inferior mesenteric artery and a good mobilization of the descending colon to allow its anastomosis to the underly

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male/ female aged over 18 years, * Histologically proven left colon or rectal adenocarcinoma OR ovarian carcinoma (with potential colorectal resection), * Scheduled surgery for left colic or rectal carcinoma// Scheduled surgery for ovarian carcinoma with potential colorectal resection, * Surgical indication of colo-rectal resection validated in RCP and confirmed during the operative exploration (ovarian cancer, * WHO Status \< 3 * Patient who has given informed, written and express consent, * Patient (s) affiliated to a French social security. Exclusion Criteria: * Contraindication to indocyanine green: thyroid adenoma, hyperthyroidism, hypersensitivity or allergy to one of the components, severe renal failure (GFR \<30 ml/min/1.73m2), * Patient with a history of abdominal vascular surgery * Patient (e) not having left colic artery on vascular mapping of preoperative abdominal-pelvic scanners, * Patient whose regular follow-up is not possible for psychological, family, social or geographical reasons, * Patient (s) under guardianship, curatorship or safeguard of justice, * Pregnant and/or breastfeeding patient,
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What it tests

  • Clamping and restauration of arterial blood of the inferior mesenteric artery
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Where

1 site
Icm Val D'Aurelle
Montpellier, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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