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Pancreatic Cancer Diagnosis With FAPI-PET Imaging

RecruitingPhase 2, Phase 3Ages 18 Years - 85 YearsAllTurku University Hospital
NCT07098598 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Staging pancreatic cancer (PC) presents a clinical challenge. Triphasic whole body CT is the primary imaging method in diagnosing, staging and during follow up. Conventional PET/CT with 18F-labelled fluorodeoxyglucose (18F-FDG) has its limitations and therefore has a secondary role in imaging pancreatic cancer patients. These conventional imaging methods are good in detecting primary tumors and distant metastasis but poor in detecting local lymph node metastasis. A new PET tracer, fibroblast activation protein inhibitor (FAPI), targets FAP, a protein overexpressed in cancer-associated fibroblasts. It presents a potential new PET imagining tool. The objective of this prospective diagnostic study is to evaluate the diagnostic efficacy of 18F-FAPI-74 PET/CT in patients with PC. The aim is to evaluate the sensitivity and specificity of 18F-FAPI-74 in detection of local lymph node metastasis

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📋 Eligibility rules (as published)
Inclusion Criteria: * Suspected primary or recurrent pancreatic cancer * Subjects must be male or female aged 18-85 years. * WHO performance score 0-2. * Subjects must be able and willing to give written informed consent and to comply with the requirements of this study protocol. Exclusion Criteria: * Vulnerable study subjects such as described in Finnish law clinical studies (disabled, children, pregnant or breast-feeding women, prisoners) will not be included. * Study subject is not able to understand the purpose of the study. * Medical conditions prohibiting whole-body PET/CT imaging.
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What it tests

  • PET/CT
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Where

1 site
Turku PET Centre, Turku University Hospital
Turku, Finland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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