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โ† Trials
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Efficacy and Safety of Brivudine in the Treatment of Herpes Zoster

RecruitingPhase 4Ages 18 Years - anyAllPeking University Third Hospital
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In plain words

What the trial is, and whether it could suit you

This multicenter RCT aims to compare the efficacy and safety of Brivudine versus Famciclovir in treating acute herpes zoster. Primary objective: Evaluate pain reduction via Numeric Pain Rating Scale (NPRS) at Day 30. Secondary objectives: Compare NPRS at Day 3/Day 7/Day 14/Day 90, time to lesion resolution, Postherpetic Neuralgia (PHN) incidence, and safety.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age โ‰ฅ18 years, regardless of gender; 2. Signed Informed Consent Form; 3. Female subjects must not plan for pregnancy or oocyte donation from screening until 1 week after the last dose and must voluntarily adopt highly effective physical contraception; male subjects must not plan for fertility or sperm donation during the same period and must voluntarily adopt highly effective physical contraception. Methods include: * Barrier methods: Condom or barrier cap (diaphragm or cervical cap); * Intrauterine device (IUD) or intrauterine system (IUS); * Surgical sterilization (bilateral oophorectomy with/without hysterectomy, total hysterectomy, bilateral tubal ligation, or vasectomy) performed โ‰ฅ6 months prior to the first dose in the subject or their partner; * Other investigator-confirmed highly effective physical contraception. Exclusion Criteria: 1. Allergy to brivudine, famciclovir, or penciclovir; 2. Current use of fluorouracil agents (e.g., 5-fluorouracil, capecitabine, tegafur, flucytosine); 3. Cancer patients currently undergoing chemotherapy; 4. Pregnant or lactating women; 5. Parkinson's disease; 6. Any condition deemed inappropriate for study participation by the investigator.
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What it tests

  • Brivudine
  • Famciclovir
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Where

4 sites
Peking University Third Hospital
Beijing, China
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Beijing, China
Peking University First Hospital
Beijing, China
Xuanwu Hospital, Capital Medical University
Beijing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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