🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Fertility And Sexual Function In CAH: CALLIOPE

Recruitingn/aAges 18 Years - 65 YearsAllUniversity of Roma La Sapienza
NCT07099456 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

This is a multicenter study designed to assess the effects of groundbreaking CAH therapies on a spectrum of clinical and biochemical outcomes, with a special emphasis on reproductive and sexual health. Fertility is a profound concern for individuals with CAH, given the high prevalence of gonadal dysfunction that arises from the hormonal derangements that characterize this complex disease. At our endo-ERN accredited center for rare diseases at Policlinico Umberto I, addressing these fertility issues in CAH patients represents a daily commitment. The revolution of the pharmacological management of CAH is one of the most debated topics to date. Data on the effects of novel management options for CAH on fertility are scarce, but the anecdotal improvements in sperm count and menstrual regularity reported in the latest clinical trials have significantly motivated us to design the CALLIOPE stud

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients, males in the age range 18-65 years and pre-menopausal females in the age range 18-55 years; * a known/new diagnosis of CAH. Exclusion Criteria: * BMI \> 40 Kg/m2; * Any other concomitant condition requiring steroid treatment; * Severe liver and/or kidney disease; * Thyroid dysfunctions (overt hyperthyroidism and hypothyroidism); * Malignant neoplasms; * Drug and alcohol abuse; * Use of drugs acting on hormonal levels (e.g. antiandrogens); * Psychiatric diseases; * Postmenopausal women; * Women taking combined oral contraceptive pill (women) or other contraceptives will require stability for at least 6 months.
💊

What it tests

  • Not listed
📍

Where

1 site
Department of Experimental Medicine, Sapienza University of Rome
Rome, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy