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Image Detection of Impaired Microcirculatory Reperfusion

Recruitingn/aAges 18 Years - anyAllUniversity of Cincinnati
NCT07099599 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, causing permanent damage to that area of the brain. That damage can result in loss of normal function to a patient's vision, strength, sensation, balance, or speech. These changes can remain permanent if blood flow is not restored to the brain. Thankfully, there are treatments available to help get rid of these blood clots. One of these treatments is a procedure to physically remove the blood clot causing stroke. This practice is now routinely done at all major stroke centers. Special imaging for stroke is now available at these major stroke centers. This imaging looks at blood flow in and around

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults greater than or equal to 18 years of age * Last known normal (LKN) within 24 hours * Ischemic stroke due to anterior circulation LVO (intracranial internal carotid artery \[ICA\], proximal middle cerebral artery \[M1\], M1/M2 bifurcation, or proximal dominant M2 occlusion) * mTICI2c or mTICI3 on digital subtracted angiography (DSA) following mechanical thrombectomy Exclusion Criteria: * Significant renal insufficiency (glomerular filtration rate \<30mg/ml/min2 while not on dialysis) * Contraindication to iodinated contrast * Contraindication to magnetic resonance imaging (e.g., pacemaker incompatibility) * Prior significant stroke in same vascular territory ipsilateral stroke * Tandem vessel occlusion (i.e., extracranial ICA and ipsilateral intracranial M1/M2 occlusion) * Greater than 4 clot retrieval attempts * Enrollment in another acute stroke interventional study (with the exception of thrombectomy device registries) * Pregnancy * Prisoners
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What it tests

  • CT Perfusion
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Where

1 site
University of Cincinnati
Cincinnati, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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