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Hyaluronic Acid and Polynucleotides in Ridge Preservation

RecruitingNAAges 25 Years - anyAllUniversity of Parma
NCT07099846 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to test the use of a bovine-derived bone graft combined with a polynucleotides-rich hyaluronic acid (PNHA) gel for the preservation of the bone after a tooth extraction (alveolar ridge preservation) and to test the performance of a fully-digital workflow to rehabilitate the site with a dental implant. 40 patients in need for a single tooth extraction will be recruited at Centro di Odontoiatria, Università di Parma and they will be randomly assigned to 2 groups: extraction and spontaneous healing or extraction and regeneration of the site with a bovine-derived bone graft combined with a PNHA gel. At 4 months after extraction an implant will be placed in the extraction site, which will be rehabilitated with a fully-digital workflow and patients will be followed up at up to 12 months post rehabilitation. Two 3D x-rays with a small field of view will be performed imm

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≥25-year-old males and females; * good systemic health (self-assessment); * presence of an unrestorable/hopeless tooth with periodontal attachment and buccal bone preserved at least for 2/3rd of the root and not associated with acute periapical pathology; * full mouth bleeding and plaque scores ≤ 25% Exclusion Criteria: * uncontrolled or untreated periodontal disease; * history of local (head and neck) radiation therapy in the past 5 years; * acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic lesion are eligible); * medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone metabolism (e.g. rheumatoid arthritis, osteoporosis) or transmittable diseases (e.g. HIV-related disease); * history of alcohol or drug abuse; * smokers of ≥10 cigarettes a day; * self-reported pregnancy or lactation.
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What it tests

  • regeneration of post extraction socket with biomaterials
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Where

2 sites
Centro di Odontoiatria, Dipartimento di Medicina e Chirurgia, Università di Parma
Parma, Italy
Centro di Odontoiatria
Parma, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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