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Effect of Losartan on the Neurohumoral Axis and Ventricular Remodeling of Patients With Severe Aortic Regurgitation Undergoing Valve Surgery.

RecruitingPhase 4Ages 18 Years - 85 YearsAllVitor Emer Egypto Rosa
NCT07099859 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Why Is This Study Important? The heart has valves that help control blood flow. Aortic regurgitation (AR) is a condition where one of these valves (the aortic valve) doesn't close properly, causing blood to leak back into the heart. Over time, this makes the heart work harder and grow larger (remodeling) to keep up. Many patients with severe AR need valve replacement surgery to fix this problem. After surgery, the heart doesn't have to work as hard, and over time, it can shrink back to a healthier size (reverse remodeling). However, doctors don't know if medications can help speed up or improve this healing process. This study aims to find out if a common blood pressure medication, losartan, can help the heart recover better after surgery. What Do the Investigators Already Know? Doctors often prescribe medications like ACE inhibitors, angiotensin receptor blockers (ARBs), beta-blockers

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📋 Eligibility rules (as published)
Inclusion criteria: * Age ≥ 18 years; * Postoperative period of aortic valve replacement surgery due to severe aortic regurgitation of any etiology; * Signed Informed Consent Form. Exclusion Criteria: To avoid potential bias in data interpretation, the following patients will be excluded: * Those who underwent cardiac surgery in the context of cardiogenic shock or infective endocarditis; * Patients with ischemic cardiomyopathy; * Patients with other significant concomitant valvular diseases. Patients with conditions where losartan use may be harmful will also be excluded, including: * Chronic kidney disease with an estimated glomerular filtration rate (eGFR \< 30 ml/min/1.73 m²); * Systolic blood pressure (SBP) \< 90 mmHg at the time of randomization; * Elevated serum potassium (K \> 5.5 mEq/L) at the time of randomization; * Pregnancy; * Known intolerance or allergy to losartan.
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What it tests

  • Losartan 50 mg
  • Placebo
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Where

1 site
Heart Institute of the School of Medicine of the University of São Paulo
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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