AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms

RecruitingNAAges 6 Months - 18 YearsAllJeffrey Pernica
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

In North America, up to 5% of preschoolers develop community-acquired pneumonia (CAP) every year. Pneumonia is the second-leading reason for paediatric hospitalization in both Canada and the US; approximately 20% of children hospitalized with CAP may need intensive care, which can result in significant morbidity. Given this burden of disease, it is critical that CAP is managed appropriately. Specific therapy for CAP is dependent on microbiologic aetiology, as bacterial disease will improve with antibiotic treatment.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Children aged 6 month to 18 years presenting to the Emergency Department who are diagnosed with CAP and are well enough to be discharged home (i.e. 'non-severe' CAP) will be eligible. They must have a fever (on exam or by history) and at least one of: * Tachypnoea measured at triage (\>60 bpm for age \<1, \>50 for 1-2 years of age, \>40bpm for 2-4 years of age, and \>30bpm for \>4 years of age) * Cough on exam or by history * Increased work of breathing on exam * Auscultatory finding (focal crackles, bronchial breathing, etc.) consistent with CAP Exclusion Criteria: Children will be excluded if they have any of the following * Cystic Fibrosis * Anatomic Lung Disease * Bronchiectasis * Chronic Lung Disease requiring home oxygen or home ventilation * Congenital heart Disease (requiring specific medical treatment or with exercise restrictions), * History of repeated aspiration/velopharyngeal incompetence * Malignancy * Immunodeficiency (primary, acquired or iatrogenic) * Pneumonia previously (clinically) diagnosed within the past month (that was presumed to have resolved prior to the episode prompting the current visit to the ED) * Lung abscess within the past 6 months * Children who present with ongoing fever after 4 days of amoxicillin, cefprozil, cefuroxime, levofloxacin, moxifloxacin or doxycycline are not eligible; as this duration of therapy with these drugs would normally be sufficient to treat bacterial CAP, a different approach would be required (ie. the care pathway as written might not be appropriate). * Children will not be eligible to participate more than once
๐Ÿ’Š

What it tests

  • The novel care pathway intervention
  • Usual Care Alone
๐Ÿ“

Where

6 sites
Alberta Children's hospital
Calgary, Canada
Stollery Children's Hospital
Edmonton, Canada
BC Children's Hospital
Vancouver, Canada
McMaster Children's Hospital
Hamilton, Canada
Children's Hospital of Eastern Ontario (CHEO)
Ottawa, Canada
The Hospital for Sick Children
Toronto, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy