An Open-label, Single-arm Clinical Study to Evaluate the Safety and Preliminary Efficacy of OriV508 Injection in Treating Relapsed/Refractory Hematological Malignancies

Inclusion Criteria: 1. Aged 18 - 75 years. 2. ECOG scores 0-1. 3. Expected survival time ≥ 12 weeks. 4. Have a record of confirmed multiple myeloma (MM) according to IMWG criteria, or a record of histologically confirmed aggressive B-cell non-Hodgkin lymphoma (B-NHL). According to the definition of the 2022 World Health Organization (WHO) classification, the pathological types of aggressive B-NHL include: diffuse large B-cell lymphoma, not otherwise specified; diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements; high-grade B-cell lymphoma, not otherwise specified; primary mediastinal B-cell lymphoma; mantle cell lymphoma; grade 3b follicular lymphoma; large B-cell lymphoma transformed from indolent B-NHL. 5. For MM subjects only: (1) Have received at least 2 lines of anti-tumor therapy, with each line of therapy undergoing at least one complete treatment cycle, and have experienced disease progression during or within 12 months after the last treatment; or be judged by the investigator as double-refractory to immunomodulators and proteasome inhibitors, and did not achieve a minimal response (MR) or better during the last treatment or experienced disease progression within 60 days after the end of treatment. (2) Have measurable lesions during the screening period, meeting any of the following criteria: (a) Serum M-protein ≥ 0.5 g/dL; (b) Urine M-protein≥ 200 mg/24h; (c) Involved free light chain (FLC) level ≥10 mg/dL provided serum FLC ratio is abnormal; (d) Plasma cell percentage ≥30% detected by bone marrow aspirate/biopsy; (e) Presence of at least one extramedullary lesion with a maximum diameter ≥ 2 cm. 6. For aggressive B-NHL subjects only: (1) Have received at least 2 lines of anti-tumor therapy, and are refractory to the last line of therapy (at least 2 cycles) (best response is PD or SD) or have experienced disease progression after the end of treatment. Previous treatments must include standard treatment regimens with anti-CD20 monoclonal antibodies (except for subjects with CD20-negative tumors) and anthracyclines; (2) Have at least one measurable lesion during the screening period: lymph node lesions must have a longest diameter \> 1.5 cm, and extranodal lesions must have a longest diameter \> 1.0 cm. 7. Hemogram meets the following requirements: * Hemoglobin ≥ 6 g/dL (no red blood cell transfusion within 1 week prior to screening, recombinant human erythropoietin is permitted); * Absolute neutrophil count (ANC) ≥ 750 /μL (no granulocyte colony-stimulating factor (G-CSF) used within 1 week prior to screening or no pegylated G-CSF used within 2 weeks prior to screening); * Platelet count ≥ 50,000 /μL; * Lymphocyte count ≥ 500 /μL. 8. Renal function: Estimated glomerular filtration rate (eGFR) (Modification of Diet in Renal Disease (MDRD) equation) ≥ 40 mL/min/1.73m2 (If the eGFR of an MM subject is \< 40 mL/min/1.73m2, the Investigator may decide whether to enroll based on clinical indications). 9. Liver function: Alanine transaminase (ALT) and aspartate transaminase (AST) ≤ 3.0 × upper limit of normal (ULN), total bilirubin ≤ 1.5 × ULN (for subjects with Gilbert's syndrome or liver invasion by tumor, ALT and AST ≤ 5.0 × ULN and total bilirubin ≤ 3 × ULN are permitted). 10. Cardiac function: Left ventricular ejection fraction ≥ 45%. 11. Pulmonary function: Pulse oxygen saturation ≥ 92% without oxygen inhalation. 12. Women with childbearing potential must have a negative blood pregnancy test and not be in the lactation period. 13. Men and women with childbearing potential must agree to use effective contraceptive measures from the time of signing the informed consent form (ICF) until 1 year after the investigational drug administration. 14. Men and women with childbearing potential must agree not to donate reproductive cells such as sperm or eggs (oocytes) from the time of signing the ICF until 1 year after the investigational drug administration. 15. The participant or their legally authorized representative agrees to participate in this clinical trial and signs the ICF, indicating that he/she understands the objective and procedures of this clinical trial and is willing to participate in the study. Exclusion Criteria: 1. The subject has received the following therapy prior to signing the ICF: * Small molecule targeted therapy, epigenetic therapy, or treatment with an investigational drug or used an invasive investigational medical device within 14 days or at least 5 half-lives, whichever is longer; * Immunosuppressive agent therapy (such as tacrolimus, mycophenolate mofetil, etc.) within 28 days; * Monoclonal antibody treatment within 21 days; * Cytotoxic therapy within 14 days; * Proteasome inhibitor therapy within 14 days; * Immunomodulator agent therapy within 7 days; * Therapeutic dose of corticosteroids (defined as prednisone ≥ 20 mg/day or equivalent dose of other corticosteroids) within 72 hours, but physiological replacement dose, topical and inhaled corticosteroids are permitted; * Radiotherapy within 28 days (only for subjects whose radiation field covers \> 5% of bone marrow reserve). 2. Received autologous hematopoietic stem cell transplantation within 24 weeks prior to signing the ICF. 3. Received organ transplantation or allogeneic hematopoietic stem cell transplantation. 4. Have other malignant tumors prior to screening, except for the following cases: malignant tumors that have received radical treatment and have no known active disease within 2 years prior to screening; or adequately treated non-melanoma skin cancer with no evidence of active disease. 5. Previously treated with any viral therapy using vesicular stomatitis virus G (VSVG)-pseudotyped virus. 6. Known active central nervous system involvement or clinical signs of meningeal involvement. 7. Complicated with severe uncontrolled active infections (bacterial, viral, fungal, etc.). 8. Have active autoimmune diseases (such as C