A Study to Evaluate the Safety, Tolerability, PK/PD of HEC-007 Injection in Healthy and Overweight/Obese Subjects

Inclusion Criteria: SAD 1. Subjects understand and comply with the study procedures, voluntarily participate, and sign the informed consent form. 2. Healthy adult subjects (including borderline values) aged 18 to 45 years, regardless of sex. 3. Male subjects weigh no less than 50 kg, and female subjects weigh no less than 45 kg. BMI =Body weight (kg)/height2 (m2), with a body mass index ranging from 19.0 to 35.0 kg/m2 (including boundary values). 4. Normal results or abnormalities deemed clinically insignificant by the investigator in vital signs, physical examination, laboratory tests, electrocardiogram, chest CT, abdominal ultrasound (liver, gallbladder, spleen, pancreas, and both kidneys), and thyroid ultrasound. 5. Female subjects of childbearing potential or male subjects must agree to use effective contraception from signing the informed consent until 6 months after the last administration of the investigational product to avoid pregnancy or impregnating a partner, with no plans for sperm or egg donation or pregnancy. 6. Glycated hemoglobin (HbA1c) \<5.7% during the screening period. MAD 1\. Subjects understand and comply with the study procedures, voluntarily participate, and sign the informed consent form. 2\. Age between 18 to 65 years (inclusive), both male and female. 3. Obesity: BMI ≥28.0 kg/m2; or overweight: 24.0 \<BMI \<28.0 kg/m2, and with at least one of the following manifestations: prediabetes (as detailed in 14.4), hypertension, dyslipidemia, fatty liver, weight-bearing joint pain, obesity-related dyspnea, or obstructive sleep apnea syndrome. 4\. At screening, weight change of \< 5% over at least 12 weeks of diet and exercise control alone. 5\. Female subjects of childbearing potential or male subjects must agree to use effective contraceptionfrom signing the informed consent until 6 months after the last administration of the investigational product to avoid pregnancy or impregnating a partner, with no plans for sperm or egg donation or pregnancy. 6\. Glycated hemoglobin (HbA1c) \<6.5% during the screening period. Exclusion Criteria: SAD 1. Those diagnosed with type 1, type 2, or other types of diabetes before screening; 2. History or family history of medullary thyroid carcinoma (MTC), thyroid C-cell hyperplasia, or multiple endocrine neoplasia syndrome type 2 (MEN2) during screening, or genetic predisposition to MTC; 3. Acute, chronic, or suspected pancreatitis during screening, or prior pancreatectomy; 4. Those diagnosed with any malignancy within 5 years before screening (except for basal cell carcinoma treated curatively and considered cured); 5. Presence of clinically significant diseases (including but not limited to gastrointestinal, renal, hepatic, neurological, hematological, endocrine, oncological, pulmonary, immunological, psychiatric, or cardiovascular disorders) during screening; 6. Diseases or conditions affecting gastric emptying or gastrointestinal nutrient absorption during screening; 7. Major surgery within 3 months before screening or planned surgery during the study; 8. History of hypersensitivity to the investigational product or any of its components, or allergic constitution (allergy to two or more drugs or foods). 9. Use of medications (including prescription drugs, over-the-counter drugs, herbal medicines, health supplements, etc.) within 3 months prior to screening that, in the investigator's judgment, significantly affect weight or glucose metabolism; 10. Individuals who have undergone bariatric surgery prior to screening; 11. Those with a history of recurrent skin disorders (e.g., urticaria) or skin lesions at the administration site; 12. Those who received chronic (lasting more than 2 weeks) systemic glucocorticoid therapy (excluding topical, intraocular, intranasal, intra-articular, or inhaled formulations) within 3 months prior to screening, or systemic glucocorticoid therapy within 1 month prior to screening; 13. Female subjects with HbA1c \<110 g/L or male subjects with HbA1c \<120 g/L at screening, or any other known condition that interferes with HbA1c measurement; 14. Those with suicidal behaviors or ideation within 6 months prior to screening; 15. Use of GLP-1R, GLP-1R/GIPR, GLP-1R/GCGR, or GLP-1R/GIPR/GCGR agonists within 6 months prior to screening; 16. Those with regular alcohol consumption within 3 months prior to screening, defined as more than 14 units of alcohol per week (1 unit = 360 mL beer, 45 mL spirits with 40% alcohol, or 150 mL wine); or those with a positive alcohol breath test during screening; or those unable to comply with the protocol's alcohol restrictions; 17. Those with a history of drug abuse or illicit drug use within 2 years prior to screening, or those with a positive urine drug screen before administration; 18. Smoking more than 5 cigarettes per day within 3 months prior to screening or inability to abstain from smoking during intensive PK blood sampling; 19. Those with a history of needle or blood phobia, intolerance to venipuncture, or difficulty in blood collection; 20. Those with positive results for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody, or Treponema pallidum-specific antibody; 21. Alanine aminotransferase \>1.5 × upper limit of normal (ULN), aspartate aminotransferase \>1.5 × ULN, alkaline phosphatase \>1.5 × ULN, or total bilirubin \>1.5 × ULN at screening; 22. Those with blood amylase or lipase \> ULN at screening; 23. Those with serum calcitonin ≥20 ng/L at screening; 24. Those with fasting blood glucose ≥6.1 mmol/L or \<3.9 mmol/L at screening; 25. Those with glomerular filtration rate (GFR) \<90 mL/min/1.73m2 at screening; 26. Fridericia-corrected QT interval (QTcF=QT/RR0.33) \>450 ms (for male) or \>470 ms (for female) on 12-lead ECG at screening; 27. Use of strong inhibitors or inducers of hepatic metabolic enzymes (CYP1A2, 2A6, 2C8, 2C19, 3A4, and 3A5) within 4 weeks prior to the first dose, including st