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Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2

RecruitingNAAges 18 Years - 65 YearsAllGlostrup University Hospital, Copenhagen
NCT07105514 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults. The main scientific questions are: * Does supplementation with IPA increase the abundance of regulatory T cells in the blood? Regulatory T cells are believed to play an important role in preventing autoimmune diseases. * Does supplementation with IPA increase the concentration of brain-derived neurotrophic factor (BDNF) in the blood? BDNF is believed to play an important role in maintaining brain health. * Does supplementation with IPA affect blood analyses commonly performed to assess the risk of metabolic disorders like type 2 diabetes and cardiovascular diseases? Participants will: * Take capsules to achieve a total daily dose of 1000 mg of IPA or placebo: 500 mg every morning and 500 mg every evening for 14 days. * Visit th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy women and men ≥18 and ≤65 years of age * Deemed mentally and physically able to participate Exclusion Criteria: * Diagnosis of gut-, heart-, liver-, kidney or immune-related disorders * Use of antibiotics within the last month * Pregnancy, lactation or childbirth within the last five months * Use of prescription medication
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What it tests

  • Indole-3-propionic acid (IPA)
  • Placebo
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Where

1 site
Optic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet-Glostrup
Glostrup Municipality, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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