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Effect of Dexamethasone on Labour Induction in Term Pregnancies

RecruitingEARLY Phase 1Ages 18 Years - anyFemaleCairo University
NCT07109258 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies. Primary outcome: The interval between initiation of induction and beginning of the active phase of labour. Secondary outcomes: * Duration of active phase of labour (starting with cervical dilatation of 4-5 cm up to full cervical dilatation). * Duration of second stage of labour * Mode of delivery. * Fetal outcome. Group A: Will receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL). Group B: Will receive vaginal misoprostol 25 ฮผg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h. Group C: Will receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 ฮผg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years. * Nulliparous. * Vertex presentation. * Singleton pregnancy. * Gestational age โ‰ฅ 39 weeks according to a reliable date for the last menstrual period or a first-trimester ultrasound evaluation. * No contraindication for vaginal delivery. Exclusion Criteria: * Indication for cesarean section e. g. Placenta previa, intrauterine growth retardation, non-vertex presentation and previous cesarean section. * Maternal medical disorders as diabetes mellitus and severe pre-eclampsia. * Preterm labour and preterm rupture of membranes. * Gestational age \<39 weeks of gestation. * Fetal macrosomia \> 4kg (estimated by u/s).
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What it tests

  • Dexamethasone (Decadron) 8mg IM injection
  • Misoprostol 25 mcg
  • Both Misoprostol 25 mcg & Dexamethasone 8mg IM injection
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Where

1 site
Cairo University Hospital (Kasr Al Ainy)
Cairo, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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