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Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers

RecruitingNAAges 18 Years - anyAllMedical University of Graz
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In plain words

What the trial is, and whether it could suit you

This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian Ayurvedic medicine system as antioxidants and anti-inflammatory agents for treating conditions such as rheumatoid arthritis, chronic bronchitis, asthma, and chronic inflammatory bowel diseases (ulcerative colitis and Crohn's disease). The β-configured pentacyclic triterpenic acids in B. serrata include 3-acetyl-11-keto-β-boswellic acid (AKBBA), 11-keto-β-boswellic acid (KBBA), β-boswellic acid (BBA), and 3-acetyl-β-boswellic acid (ABBA). These compounds, which constitute approximately 14% of the lipophilic fractions of the B. serrata extract, are the major active components. Boswellia serrata is marketed as a food supplement in accordance with EU Directive 2002/46/EC. S

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age: ≥18 years Exclusion Criteria: * Not pregnant or breastfeeding * No renal or liver insufficiency * No neurological/dermatological/cardiovascular diseases * No chronic pain and/or use of analgesics * No use of anticoagulants * No use of antidepressants * No use of MAO inhibitors * No use of St. John's Wort * No use of medications affecting the CYP mechanism * No allergies to Boswellia serrata or capsaicin"
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What it tests

  • Boswellia serrata extract
  • Placebo
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Where

1 site
Medical University of Graz
Graz, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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