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Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

RecruitingNAAges 21 Years - anyAllOhio State University Comprehensive Cancer Center
NCT07111234 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical trial studies how the flavors and synthetic coolant properties in oral nicotine pouches (ONPs) compare to one another and how these characteristics are perceived by users. ONPs are placed between the gum and lip, and the nicotine is absorbed in the mouth. They have a strong potential for harm reduction if smokers can switch to using them, and they are growing in popularity. One factor that could be contributing to the increase in popularity is the wide range of flavors, including mint or menthol. With recent flavor restriction policies that have gone into effect in certain areas of the United States, ONPs are now including synthetic cooling agents (WS-3) in place of the flavors. They provide a cooling sensation, but do not have a characterizing flavor, like mint or menthol, allowing them to be sold where flavor restriction policies are in place. Learning more about the flav

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 21 years or older * Willing to complete study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits * Ability to read and speak English * Has smoked \>= 100 cigarettes * Smokes \>= 5 cigarettes/day for past year Exclusion Criteria: * Use other tobacco products (including ONPs) more than 10 days per month * Unstable or significant psychiatric conditions (past and stable conditions allowed) * Pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test before each visit) * History of cardiac event or distress within the past 3 months * Currently attempting to quit all tobacco use
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What it tests

  • Carbon Monoxide Measurement
  • Nicotine Oral Pouch
  • Questionnaire Administration
  • Smoke usual brand cigarette
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Where

1 site
Ohio State University Comprehensive Cancer Center
Columbus, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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