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Optimal Ventilation for Cardiac Arrest

RecruitingNAAges 37 Weeks - 18 YearsAllChildren's Hospital of Philadelphia
NCT07114510 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Invasive airway in place at the start of CPR or airway placed within the first 5 minutes * Received at least 1 minute of CPR. Exclusion Criteria: * Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care. * Brain death determination prior to the CPR event. * Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes). * Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR
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What it tests

  • OPTI-VENT Bundle
  • Transition
  • None - control
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Where

20 sites
CHOC
Orange, United States
Lucile Packard Children's Hospital Stanford
Palo Alto, United States
Children's Hospital Colorado
Denver, United States
Nemours Children's Health
Wilmington, United States
Children's Healthcare of Atlanta
Atlanta, United States
Riley Children's Health
Indianapolis, United States
Stead Family Children's Hospital
Iowa City, United States
Boston Children's Hospital
Boston, United States

…and 12 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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