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Radiation Combined With BCMA/CD3 Bispecific Antibody Therapy for Solitary Bone Plasmacytoma With Mild Bone Marrow Infiltration

RecruitingPhase 2Ages 18 Years - 78 YearsAllInstitute of Hematology & Blood Diseases Hospital…
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In plain words

What the trial is, and whether it could suit you

This is a prospective, single-arm, single-center clinical trial designed to evaluate the safety and efficacy of radiation combined with a BCMA/CD3 bispecific antibody (CM336) in patients with solitary bone plasmacytoma (SBP) with mild bone marrow infiltration.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * ≥18 years old * Histologically confirmed SBP with \<10% clonal plasma cells in marrow * ECOG ≤ 2 * No prior anti-myeloma therapy. Previous local radiotherapy for SBP is not an exclusion criterion. * Meets laboratory and imaging criteria Exclusion Criteria: 1. Patients who have previously received anti-plasma cell therapy, including melphalan, cyclophosphamide, proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, bispecific antibodies, or chimeric antigen receptor T-cell (CAR-T) therapy. 2. Any condition that, in the opinion of the investigator, would make the patient unsuitable for participation in this study.
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What it tests

  • BCMA/CD3 bispecific antibody (CM336)
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Where

1 site
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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