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← Trials
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Serial Assessment of Fertility Experiences

Recruitingn/aAges 8 Years - anyAllChildren's Hospital Medical Center, Cincinnati
NCT07116772 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children. A second goal is to see how hydroxyurea affects pregnancy outcomes, by comparing people who take the medicine to those who don't.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with documented sickle cell anemia (SCA). * At least 8 years of age at the time of enrollment. * Enrolled on the EXTEND or SACRED study. * Provide informed consent. * Able to take part in all parts of the study, including treatments, check-ups, and follow-up visits. Exclusion Criteria: * Currently taking part in another treatment study (not EXTEND or SACRED). * Has received other treatments for sickle cell disease in the past 6 months.
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What it tests

  • Not listed
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Where

3 sites
Centro de Obstetricia y Ginecologia
Santo Domingo, Dominican Republic
Caribbean Institute for Health Research, University of West Indies
Kingston, Jamaica
Buganda Medical Centre
Mwanza, Tanzania
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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