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Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction

RecruitingNAAges 18 Years - 80 YearsAllCentre Hospitalier Universitaire de Nīmes
NCT07118410 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Exercise is essential in cardiac rehabilitation for heart failure patients.Aerobic training and resistance training are both recommended. Resistance training improves muscle mass and strength and also improves the remodeling of cardiac function, thus reducing exercise intolerance in these patients. However, to obtain these adaptations, resistance training must be done at moderate to high intensities, which cannot always be sustained by the most fragile and deconditioned patients, such as those with reduced ejection fraction (Heart failure with reduced Ejection Fraction). Blood flow restriction (BFR) by vascular occlusion training is an interesting alternative to conventional resistance training for these deconditioned patients. Preclinical and clinical studies have shown that, for low-intensity regimens, resistance training and blood flow restriction by vascular occlusion improves muscl

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📋 Eligibility rules (as published)
Inclusion Criteria: * LVEF ≤ 50% * Patients with an indication for cardiovascular rehabilitation in the first stay or not (according to national recommendations, as soon as possible after an exacerbation or at any time in a patient with chronic heart failure) (Bigot et al., 2024) * No medical contraindication to physical activity * Patient has given free and informed consent and signed the consent form * Patient affiliated with or benefiting from a health insurance scheme Exclusion Criteria: * Patient participating in another Category I interventional study, or having participated in another interventional study in the last month * Patient in an exclusion period determined by a previous study * Patient under court protection, guardianship or curatorship * Unable to provide informed consent, or patient refuses to sign consent form * Pregnant, parturient or breast-feeding patient * Moderate to severe peripheral arterial disease. Arterial Doppler scan for arterial stenosis, with measurement of femoral and distal flows. * Active or recent deep vein thrombosis. Check with venous Doppler ultrasound, looking for venous compressibility at the roots of the thighs, and 4-point venous ultrasound. * Medication known to alter the effects of ischemic conditioning (cyclosporine, glibenclamide). * Uncontrolled arterial hypertension * Severe valvular disease
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What it tests

  • Application of a vascular restriction device during resistance training
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Where

1 site
Nîmes University Hospital
Nîmes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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