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ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Angers
NCT07119957 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the study is to build up a bio-collection of biological samples from patients with cirrhosis. Further work using this bio-collection will permit to describe the influence of different exposome factors (nutrition, physical activity, socio-demographic conditions, tobacco, alcohol, pollutants) on the occurrence of the main type of liver cancer (called HCC). Indeed, in the vast majority of cases, HCC develops within cirrhosis, and the factors that precipitate the progression of cirrhotic patients to HCC remain largely unknown.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Presence of metabolic and/or alcoholic steatotic liver disease, as defined by the new nomenclature (MASLD, ALD, or mixed MetALD) * Liver biopsy performed (less than 2 months ago) or planned as part of treatment for diagnosis of cirrhosis ("Control" group without HCC) or diagnosis of HCC on cirrhosis ("Case" group) * Patient affiliated to or benefiting from a social security scheme * Patient having signed an informed consent to participate in the study (bio-collection) Exclusion Criteria: * Causes of chronic liver disease other than MASLD, ALD, or MetALD * Decompensation of cirrhosis in the two years prior to inclusion (ascites, hepatic encephalopathy, gastrointestinal variceal hemorrhage, liver failure, hepatorenal syndrome) * For the "Control" group: history of hepatocellular carcinoma * Pregnant, breast-feeding or parturient women * Persons deprived of liberty by judicial or administrative decision
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What it tests

  • Blood, urine and stool biocollection
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Where

4 sites
Angers University Hospital
Angers, France
Centre Eugène Marquis (Oncology center)
Rennes, France
Rennes University Hospital, Hepatogastroenteroly Department
Rennes, France
Tours University Hospital, HepatoGastroenterology Department
Tours, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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